Immunotherapy for glioblastoma: are we finally getting closer?

Ribozymes as therapeutic agents: are we getting closer?

The biology of ribozymes has come far since the initial seminal observations of self-cleaving molecules in Tetrahymena (1) and ribonuclease P (2). With the discovery of the hammerhead ribozyme (3) came the realization that it could be utilized to potentially disrupt the expression of any target gene in trans (i.e., acting from outside the target gene sequence) (4). As different types of catalyt...

Why are we not getting any closer to preventing suicide?

Adaptive significance of play: Are we getting closer?

Life history theory predicts that animals whose activities impose time, energy or survivorship costs at one stage of their lives will subsequently suffer incremental decreases in fitness unless there are compensatory benefits. Play, a widespread activity among juvenile mammals and several orders of birds' appears costly, yet its adaptive significance is poorly understood despite over 15 years o...

Defining remission in psoriatic arthritis: are we getting closer?

Immunotherapy for glioma: getting closer to the clinical arena?

PURPOSE OF REVIEW During recent years different approaches have been explored to raise effective antitumor responses against brain tumors and particularly glioblastomas (GBMs). In most cases, cancer vaccines were based on autologous dendritic cells loaded with GBM peptides or whole tumor lysates. Many phase I-II studies showed that such strategy is feasible and nontoxic but failed to provide co...